{"id":2615,"date":"2025-08-11T09:33:14","date_gmt":"2025-08-11T02:33:14","guid":{"rendered":"https:\/\/nopphatnguoi.vn\/blog\/co-the-dieu-chinh-nhip-sinh-hoc-nhu-the-nao-khi-nhiet-do-thay-doi\/"},"modified":"2025-08-11T09:33:14","modified_gmt":"2025-08-11T02:33:14","slug":"co-the-dieu-chinh-nhip-sinh-hoc-nhu-the-nao-khi-nhiet-do-thay-doi","status":"publish","type":"post","link":"https:\/\/nopphatnguoi.vn\/blog\/co-the-dieu-chinh-nhip-sinh-hoc-nhu-the-nao-khi-nhiet-do-thay-doi\/","title":{"rendered":"C\u01a1 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh nh\u1ecbp sinh h\u1ecdc nh\u01b0 th\u1ebf n\u00e0o khi nhi\u1ec7t \u0111\u1ed9 thay \u0111\u1ed5i?"},"content":{"rendered":"<div>\n<div>\n<p>M&#7897;t nghi&ecirc;n c&#7913;u g&#7847;n &#273;&acirc;y &#273;&atilde; &#273;&#432;a ra ph&aacute;t hi&#7879;n quan tr&#7885;ng v&#7873; kh&#7843; n&#259;ng c&#7911;a &#273;&#7891;ng h&#7891; sinh h&#7885;c con ng&#432;&#7901;i trong vi&#7879;c duy tr&igrave; nh&#7883;p &#273;i&#7879;u 24 gi&#7901; trong &#273;i&#7873;u ki&#7879;n nhi&#7879;t &#273;&#7897; cao. C&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u t&#7915; Trung t&acirc;m Khoa h&#7885;c To&aacute;n h&#7885;c v&agrave; L&yacute; thuy&#7871;t Li&ecirc;n ng&agrave;nh RIKEN (iTHEMS) t&#7841;i Nh&#7853;t B&#7843;n &#273;&atilde; th&#7921;c hi&#7879;n nghi&ecirc;n c&#7913;u n&agrave;y, l&agrave;m s&aacute;ng t&#7887; c&#417; ch&#7871; gi&uacute;p c&#417; th&#7875; ch&uacute;ng ta &#273;i&#7873;u ch&#7881;nh c&aacute;c ho&#7841;t &#273;&#7897;ng h&agrave;ng ng&agrave;y.<\/p>\n<p>&#272;&#7891;ng h&#7891; sinh h&#7885;c l&agrave; m&#7897;t h&#7879; th&#7889;ng ph&#7913;c t&#7841;p gi&uacute;p c&#417; th&#7875; ch&uacute;ng ta &#273;&#7891;ng b&#7897; h&oacute;a c&aacute;c ho&#7841;t &#273;&#7897;ng sinh h&#7885;c v&#7899;i chu k&#7923; 24 gi&#7901; c&#7911;a ng&agrave;y &#273;&ecirc;m. Tuy nhi&ecirc;n, nhi&#7879;t &#273;&#7897; c&oacute; th&#7875; &#7843;nh h&#432;&#7903;ng &#273;&#7871;n t&#7889;c &#273;&#7897; c&#7911;a c&aacute;c ph&#7843;n &#7913;ng sinh h&#7885;c, t&#7915; &#273;&oacute; l&agrave;m thay &#273;&#7893;i nh&#7883;p &#273;i&#7879;u c&#7911;a &#273;&#7891;ng h&#7891; sinh h&#7885;c. &#272;&#7875; gi&#7843;i quy&#7871;t v&#7845;n &#273;&#7873; n&agrave;y, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;&atilde; ph&aacute;t hi&#7879;n ra m&#7897;t c&#417; ch&#7871; g&#7885;i l&agrave; b&ugrave; tr&#7915; nhi&#7879;t, gi&uacute;p duy tr&igrave; s&#7921; ch&iacute;nh x&aacute;c c&#7911;a &#273;&#7891;ng h&#7891; sinh h&#7885;c.<\/p>\n<p>C&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;&atilde; &aacute;p d&#7909;ng m&#7897;t k&#7929; thu&#7853;t to&aacute;n h&#7885;c ti&ecirc;n ti&#7871;n g&#7885;i l&agrave; ph&#432;&#417;ng ph&aacute;p nh&oacute;m t&aacute;i chu&#7849;n h&oacute;a &#273;&#7875; ph&acirc;n t&iacute;ch d&#7919; li&#7879;u. Qua &#273;&oacute;, h&#7885; ph&aacute;t hi&#7879;n ra r&#7857;ng h&igrave;nh d&#7841;ng c&#7911;a chu k&#7923; gene thay &#273;&#7893;i &#7903; nhi&#7879;t &#273;&#7897; cao, v&#7899;i m&#7913;c &#273;&#7897; RNA th&ocirc;ng tin (mRNA) t&#259;ng l&ecirc;n nhanh ch&oacute;ng v&agrave; sau &#273;&oacute; gi&#7843;m d&#7847;n. S&#7921; thay &#273;&#7893;i h&igrave;nh d&#7841;ng n&agrave;y &#273;&oacute;ng vai tr&ograve; quan tr&#7885;ng trong vi&#7879;c duy tr&igrave; chi&#7873;u d&agrave;i chu k&#7923; c&#7911;a &#273;&#7891;ng h&#7891; sinh h&#7885;c.<\/p>\n<p>Khi nhi&#7879;t &#273;&#7897; t&#259;ng, h&igrave;nh d&#7841;ng c&#7911;a s&oacute;ng gene tr&#7903; n&ecirc;n kh&ocirc;ng &#273;&#7889;i x&#7913;ng, gi&#7889;ng nh&#432; r&#259;ng c&#432;a. S&#7921; thay &#273;&#7893;i h&igrave;nh d&#7841;ng n&agrave;y gi&uacute;p &#273;&#7891;ng h&#7891; sinh h&#7885;c duy tr&igrave; &#273;&#7897; ch&iacute;nh x&aacute;c. &#272;i&#7873;u th&uacute; v&#7883; l&agrave; c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u c&#361;ng ph&aacute;t hi&#7879;n ra r&#7857;ng s&#7921; thay &#273;&#7893;i h&igrave;nh d&#7841;ng n&agrave;y xu&#7845;t hi&#7879;n &#7903; nhi&#7873;u lo&agrave;i, bao g&#7891;m c&#7843; ru&#7891;i, chu&#7897;t v&agrave; n&#7845;m.<\/p>\n<p>&#272;&#7891;ng h&#7891; sinh h&#7885;c c&oacute; &#7843;nh h&#432;&#7903;ng quan tr&#7885;ng &#273;&#7871;n s&#7913;c kh&#7887;e c&#7911;a con ng&#432;&#7901;i. S&#7921; thay &#273;&#7893;i h&igrave;nh d&#7841;ng c&#7911;a &#273;&#7891;ng h&#7891; sinh h&#7885;c c&oacute; th&#7875; &#7843;nh h&#432;&#7903;ng &#273;&#7871;n kh&#7843; n&#259;ng th&iacute;ch nghi v&#7899;i thay &#273;&#7893;i m&uacute;i gi&#7901; v&agrave; l&agrave;m vi&#7879;c theo ca. C&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u hy v&#7885;ng r&#7857;ng nghi&ecirc;n c&#7913;u n&agrave;y s&#7869; gi&uacute;p ph&aacute;t tri&#7875;n c&aacute;c ph&#432;&#417;ng ph&aacute;p &#273;i&#7873;u tr&#7883; m&#7899;i cho c&aacute;c r&#7889;i lo&#7841;n sinh h&#7885;c v&agrave; c&#7843;i thi&#7879;n hi&#7875;u bi&#7871;t v&#7873; m&#7889;i quan h&#7879; gi&#7919;a nhi&#7879;t &#273;&#7897; v&agrave; &#273;&#7891;ng h&#7891; sinh h&#7885;c.<\/p>\n<p>Nghi&ecirc;n c&#7913;u n&agrave;y &#273;&atilde; &#273;&#432;&#7907;c c&ocirc;ng b&#7889; tr&ecirc;n t&#7841;p ch&iacute; PLOS Computational Biology, &#273;&oacute;ng g&oacute;p v&agrave;o l&#297;nh v&#7921;c nghi&ecirc;n c&#7913;u v&#7873; &#273;&#7891;ng h&#7891; sinh h&#7885;c v&agrave; m&#7903; ra kh&#7843; n&#259;ng &#7913;ng d&#7909;ng trong t&#432;&#417;ng lai.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u0110\u1ed3ng h\u1ed3 sinh h\u1ecdc \u0111i\u1ec1u ch\u1ec9nh nh\u1ecbp \u0111i\u1ec7u c\u1ee7a m\u00ecnh \u0111\u1ec3 b\u00f9 \u0111\u1eafp cho s\u1ef1 t\u00e1c \u0111\u1ed9ng nhi\u1ec7t g\u00e2y ra b\u1edfi nhi\u1ec7t \u0111\u1ed9. \u0110\u1ed3ng h\u1ed3 sinh h\u1ecdc thay \u0111\u1ed5i h\u00ecnh d\u1ea1ng \u0111\u1ec3 duy tr\u00ec nh\u1ecbp \u0111i\u1ec7u \u1ed5n \u0111\u1ecbnh \u1edf nhi\u1ec7t \u0111\u1ed9 cao. M\u1ed9t th\u1ee7 thu\u1eadt to\u00e1n h\u1ecdc g\u1ecdi l\u00e0 ph\u01b0\u01a1ng ph\u00e1p nh\u00f3m t\u00e1i chu\u1ea9n h\u00f3a \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3i th\u00edch l\u00e0m th\u1ebf n\u00e0o s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng n\u00e0y gi\u1eef cho chu k\u1ef3 \u1ed5n \u0111\u1ecbnh.<\/p>\n","protected":false},"author":1,"featured_media":2616,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3],"tags":[2996,2998,2997,3000,2999],"class_list":["post-2615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thoi-su","tag-dong-ho-sinh-hoc","tag-nhiet-do","tag-nhip-dieu","tag-phuong-phap-nhom-tai-chuan-hoa","tag-toan-hoc"],"_links":{"self":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/2615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/comments?post=2615"}],"version-history":[{"count":0,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/2615\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media\/2616"}],"wp:attachment":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media?parent=2615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/categories?post=2615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/tags?post=2615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}