{"id":25833,"date":"2025-11-15T03:29:58","date_gmt":"2025-11-14T20:29:58","guid":{"rendered":"https:\/\/nopphatnguoi.vn\/blog\/te-bao-co-the-con-nguoi-thoa-kem-rna-de-tranh-kich-hoat-phan-ung-mien-dich\/"},"modified":"2025-11-15T03:30:04","modified_gmt":"2025-11-14T20:30:04","slug":"te-bao-co-the-con-nguoi-thoa-kem-rna-de-tranh-kich-hoat-phan-ung-mien-dich","status":"publish","type":"post","link":"https:\/\/nopphatnguoi.vn\/blog\/te-bao-co-the-con-nguoi-thoa-kem-rna-de-tranh-kich-hoat-phan-ung-mien-dich\/","title":{"rendered":"T\u1ebf b\u00e0o c\u01a1 th\u1ec3 con ng\u01b0\u1eddi &#8220;thoa kem&#8221; RNA \u0111\u1ec3 tr\u00e1nh k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch"},"content":{"rendered":"<div>\n<p>C&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; &#273;&#7841;t &#273;&#432;&#7907;c b&#432;&#7899;c ti&#7871;n quan tr&#7885;ng trong vi&#7879;c hi&#7875;u r&otilde; vai tr&ograve; c&#7911;a glycosyl h&oacute;a RNA trong vi&#7879;c tr&aacute;nh s&#7921; ch&uacute; &yacute; c&#7911;a h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch. RNA kh&ocirc;ng b&#7883; glycosyl h&oacute;a &#273;&#432;&#7907;c coi l&agrave; d&#7845;u hi&#7879;u c&#7911;a s&#7921; x&acirc;m nh&#7853;p c&#7911;a virus ho&#7863;c vi khu&#7849;n v&agrave; ph&#7843;i &#273;&#432;&#7907;c t&#7845;n c&ocirc;ng. Tuy nhi&ecirc;n, c&aacute;c t&#7871; b&agrave;o c&#7911;a c&#417; th&#7875; ch&uacute;ng ta c&#361;ng c&oacute; RNA, v&agrave; &#273;&#7875; tr&aacute;nh g&acirc;y ra ph&#7843;n &#7913;ng vi&ecirc;m, ch&uacute;ng ta glycosyl h&oacute;a RNA.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/media.tripmap.vn\/blog-npn\/2025\/11\/te-bao-co-the-con-nguoi-thoa-kem-rna-de-tranh-kich-hoat-phan-ung-mien-dich.webp\" alt=\"From left to right: Vijay Rathinam and Vincent Graziano, first author on the sweet disguise paper. (Photo courtesy of Rathinam Lab\/UConn School of Medicine)\" width=\"100%\"><figcaption>From left to right: Vijay Rathinam and Vincent Graziano, first author on the sweet disguise paper. (Photo courtesy of Rathinam Lab\/UConn School of Medicine)<\/figcaption><\/figure>\n<p>M&#7897;t nghi&ecirc;n c&#7913;u m&#7899;i c&ocirc;ng b&#7889; tr&ecirc;n t&#7841;p ch&iacute; Nature &#273;&atilde; ch&#7881; ra r&#7857;ng, c&aacute;c t&#7871; b&agrave;o c&#7911;a c&#417; th&#7875; ch&uacute;ng ta &#273;&#7873;u c&oacute; RNA, nh&#432;ng h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch l&#7841;i b&#7887; qua ch&uacute;ng. C&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; ph&aacute;t hi&#7879;n ra r&#7857;ng, RNA c&#7911;a t&#7871; b&agrave;o ch&uacute;ng ta &#273;&#432;&#7907;c glycosyl h&oacute;a, t&#7913;c l&agrave; &#273;&#432;&#7907;c ph&#7911; m&#7897;t l&#7899;p &#273;&#432;&#7901;ng. Khi c&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; l&#7845;y RNA t&#7915; c&aacute;c t&#7871; b&agrave;o ng&#432;&#7901;i v&agrave; m&aacute;u, lo&#7841;i b&#7887; l&#7899;p &#273;&#432;&#7901;ng v&agrave; &#273;&#432;a n&oacute; tr&#7903; l&#7841;i v&agrave;o t&#7871; b&agrave;o, h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch &#273;&atilde; t&#7845;n c&ocirc;ng n&oacute;. Nh&#432;ng khi RNA v&#7851;n c&ograve;n l&#7899;p &#273;&#432;&#7901;ng, h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch &#273;&atilde; b&#7887; qua.<\/p>\n<p>Qu&aacute; tr&igrave;nh glycosyl h&oacute;a RNA n&agrave;y c&oacute; &yacute; ngh&#297;a quan tr&#7885;ng &#273;&#7889;i v&#7899;i c&#417; th&#7875; ch&uacute;ng ta. Khi c&aacute;c t&#7871; b&agrave;o ch&#7871;t v&agrave; &#273;&#432;&#7907;c h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch d&#7885;n d&#7865;p, l&#7899;p &#273;&#432;&#7901;ng tr&ecirc;n RNA ng&#259;n ch&#7863;n c&aacute;c t&#7871; b&agrave;o ch&#7871;t kh&ocirc;ng k&iacute;ch th&iacute;ch kh&ocirc;ng c&#7847;n thi&#7871;t g&acirc;y vi&ecirc;m. &#272;i&#7873;u n&agrave;y gi&uacute;p ng&#259;n ch&#7863;n c&aacute;c ph&#7843;n &#7913;ng vi&ecirc;m kh&ocirc;ng c&#7847;n thi&#7871;t v&agrave; duy tr&igrave; s&#7921; c&acirc;n b&#7857;ng c&#7911;a h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch.<\/p>\n<p>Nh&#7919;ng ph&aacute;t hi&#7879;n n&agrave;y c&oacute; th&#7875; gi&uacute;p ch&uacute;ng ta hi&#7875;u r&otilde; h&#417;n v&#7873; c&aacute;c b&#7879;nh t&#7921; mi&#7877;n. M&#7897;t s&#7889; b&#7879;nh t&#7921; mi&#7877;n, ch&#7859;ng h&#7841;n nh&#432; lupus, li&ecirc;n quan &#273;&#7871;n RNA c&#7909; th&#7875; v&agrave; c&aacute;c t&#7871; b&agrave;o ch&#7871;t k&iacute;ch ho&#7841;t h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch. B&acirc;y gi&#7901;, c&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; hi&#7875;u r&otilde; vai tr&ograve; c&#7911;a glycosyl h&oacute;a RNA trong vi&#7879;c tr&aacute;nh s&#7921; ch&uacute; &yacute; c&#7911;a h&#7879; th&#7889;ng mi&#7877;n d&#7883;ch, h&#7885; c&oacute; th&#7875; ki&#7875;m tra xem chi&#7871;n l&#432;&#7907;c n&agrave;y c&oacute; b&#7883; sai l&#7879;ch v&agrave; l&agrave;m th&#7871; n&agrave;o &#273;&#7875; s&#7917;a ch&#7919;a n&oacute;.<\/p>\n<p>Nghi&ecirc;n c&#7913;u n&agrave;y &#273;&#432;&#7907;c th&#7921;c hi&#7879;n h&#7907;p t&aacute;c v&#7899;i c&aacute;c ph&ograve;ng th&iacute; nghi&#7879;m c&#7911;a Ryan Flynn, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson v&agrave; Penghua Wang v&agrave; &#273;&#432;&#7907;c t&agrave;i tr&#7907; b&#7903;i c&aacute;c kho&#7843;n tr&#7907; c&#7845;p t&#7915; Vi&#7879;n Y t&#7871; Qu&#7889;c gia.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Nature \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o c\u1ee7a ch\u00fang ta bao ph\u1ee7 RNA b\u1eb1ng \u0111\u01b0\u1eddng \u0111\u1ec3 tr\u00e1nh k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch. Qu\u00e1 tr\u00ecnh glycosyl h\u00f3a RNA n\u00e0y ng\u0103n h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng RNA c\u1ee7a ch\u00ednh c\u01a1 th\u1ec3, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 RNA c\u00f3 trong virus v\u00e0 vi khu\u1ea9n. Nghi\u00ean c\u1ee9u n\u00e0y, do Vijay Rathinam v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1eeb Tr\u01b0\u1eddng Y h\u1ecdc UConn v\u00e0 Ryan Flynn t\u1eeb B\u1ec7nh vi\u1ec7n Nhi Boston th\u1ef1c hi\u1ec7n, c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng trong vi\u1ec7c hi\u1ec3u v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n, n\u01a1i h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng nh\u1ea7m c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n","protected":false},"author":1,"featured_media":25835,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3],"tags":[14135,19422,19419,9646,19418,19421,11360,19420],"class_list":["post-25833","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thoi-su","tag-benh-tu-mien","tag-benh-vien-nhi-boston","tag-glycosyl-hoa","tag-he-mien-dich","tag-rna","tag-truong-y-hoc-uconn","tag-vi-khuan","tag-virus"],"_links":{"self":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/25833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/comments?post=25833"}],"version-history":[{"count":0,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/25833\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media\/25835"}],"wp:attachment":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media?parent=25833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/categories?post=25833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/tags?post=25833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}