{"id":1993,"date":"2025-08-10T01:21:24","date_gmt":"2025-08-09T18:21:24","guid":{"rendered":"https:\/\/nopphatnguoi.vn\/blog\/co-the-con-nguoi-lao-hoa-nhanh-nhu-the-nao\/"},"modified":"2025-08-10T01:21:24","modified_gmt":"2025-08-09T18:21:24","slug":"co-the-con-nguoi-lao-hoa-nhanh-nhu-the-nao","status":"publish","type":"post","link":"https:\/\/nopphatnguoi.vn\/blog\/co-the-con-nguoi-lao-hoa-nhanh-nhu-the-nao\/","title":{"rendered":"C\u01a1 th\u1ec3 con ng\u01b0\u1eddi l\u00e3o h\u00f3a nhanh nh\u01b0 th\u1ebf n\u00e0o?"},"content":{"rendered":"<div>\n<div>\n<p> Qu&aacute; tr&igrave;nh l&atilde;o h&oacute;a c&#7911;a con ng&#432;&#7901;i kh&ocirc;ng di&#7877;n ra &#273;&#7891;ng &#273;&#7873;u v&agrave; c&oacute; th&#7875; t&#259;ng t&#7889;c sau tu&#7893;i 50. &#272;&acirc;y l&agrave; k&#7871;t lu&#7853;n &#273;&#432;&#7907;c &#273;&#432;a ra t&#7915; m&#7897;t nghi&ecirc;n c&#7913;u m&#7899;i nh&#7845;t &#273;&#432;&#7907;c c&ocirc;ng b&#7889; tr&ecirc;n t&#7841;p ch&iacute; Cell v&agrave;o ng&agrave;y 25 th&aacute;ng 7. C&aacute;c nh&agrave; khoa h&#7885;c &#273;&atilde; ti&#7871;n h&agrave;nh ph&acirc;n t&iacute;ch s&#7921; thay &#273;&#7893;i c&#7911;a protein theo th&#7901;i gian trong c&aacute;c c&#417; quan kh&aacute;c nhau c&#7911;a c&#417; th&#7875;. K&#7871;t qu&#7843; cho th&#7845;y r&#7857;ng, &#7903; kho&#7843;ng tu&#7893;i 50, qu&aacute; tr&igrave;nh l&atilde;o h&oacute;a d&#432;&#7901;ng nh&#432; t&#259;ng t&#7889;c &#273;&aacute;ng k&#7875;.<\/p>\n<p> Nghi&ecirc;n c&#7913;u n&agrave;y &#273;&atilde; ph&acirc;n t&iacute;ch c&aacute;c m&#7851;u m&ocirc; t&#7915; 76 ng&#432;&#7901;i c&oacute; ngu&#7891;n g&#7889;c Trung Qu&#7889;c, v&#7899;i &#273;&#7897; tu&#7893;i t&#7915; 14 &#273;&#7871;n 68, nh&#7919;ng ng&#432;&#7901;i &#273;&atilde; ch&#7871;t do ch&#7845;n th&#432;&#417;ng n&atilde;o. C&aacute;c m&#7851;u m&ocirc; n&agrave;y &#273;&#7841;i di&#7879;n cho 8 h&#7879; th&#7889;ng c&#7911;a c&#417; th&#7875;, bao g&#7891;m h&#7879; tim m&#7841;ch, mi&#7877;n d&#7883;ch v&agrave; ti&ecirc;u h&oacute;a. Qua ph&acirc;n t&iacute;ch, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;&atilde; ph&aacute;t hi&#7879;n ra s&#7921; gia t&#259;ng li&ecirc;n quan &#273;&#7871;n tu&#7893;i t&aacute;c trong bi&#7875;u hi&#7879;n c&#7911;a 48 protein li&ecirc;n quan &#273;&#7871;n b&#7879;nh. &#272;&#7891;ng th&#7901;i, h&#7885; c&#361;ng nh&#7853;n th&#7845;y c&aacute;c thay &#273;&#7893;i s&#7899;m &#7903; kho&#7843;ng tu&#7893;i 30 t&#7841;i tuy&#7871;n th&#432;&#7907;ng th&#7853;n, n&#417;i s&#7843;n xu&#7845;t c&aacute;c hormone kh&aacute;c nhau. &#272;i&#7873;u n&agrave;y ph&ugrave; h&#7907;p v&#7899;i d&#7919; li&#7879;u tr&#432;&#7899;c &#273;&oacute;, cho th&#7845;y r&#7857;ng s&#7921; ki&#7875;m so&aacute;t hormone v&agrave; chuy&#7875;n h&oacute;a l&agrave; r&#7845;t quan tr&#7885;ng &#273;&#7889;i v&#7899;i qu&aacute; tr&igrave;nh l&atilde;o h&oacute;a.<\/p>\n<p> Tuy nhi&ecirc;n, gi&#7919;a tu&#7893;i 45 v&agrave; 55, m&#7897;t &#273;i&#7875;m chuy&#7875;n &#273;&#7893;i &#273;&atilde; xu&#7845;t hi&#7879;n v&#7899;i nh&#7919;ng thay &#273;&#7893;i l&#7899;n trong m&#7913;c &#273;&#7897; protein. S&#7921; thay &#273;&#7893;i m&#7841;nh m&#7869; nh&#7845;t &#273;&#432;&#7907;c t&igrave;m th&#7845;y trong &#273;&#7897;ng m&#7841;ch ch&#7911;, &#273;&#7897;ng m&#7841;ch ch&iacute;nh c&#7911;a c&#417; th&#7875;, n&#417;i mang m&aacute;u oxy h&oacute;a ra kh&#7887;i tim. C&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;&atilde; x&aacute;c &#273;&#7883;nh &#273;&#432;&#7907;c m&#7897;t protein &#273;&#432;&#7907;c s&#7843;n xu&#7845;t trong &#273;&#7897;ng m&#7841;ch ch&#7911;, khi &#273;&#432;&#7907;c truy&#7873;n cho chu&#7897;t, k&iacute;ch ho&#7841;t c&aacute;c d&#7845;u hi&#7879;u l&atilde;o h&oacute;a t&#259;ng t&#7889;c. &#272;i&#7873;u n&agrave;y cho th&#7845;y r&#7857;ng l&atilde;o h&oacute;a kh&ocirc;ng ph&#7843;i l&agrave; m&#7897;t qu&aacute; tr&igrave;nh tuy&#7871;n t&iacute;nh, m&agrave; thay v&agrave;o &#273;&oacute; l&agrave; m&#7897;t qu&aacute; tr&igrave;nh b&#7883; &#273;&aacute;nh d&#7845;u b&#7903;i c&aacute;c giai &#273;o&#7841;n thay &#273;&#7893;i nhanh ch&oacute;ng.<\/p>\n<p> C&aacute;c ph&aacute;t hi&#7879;n n&agrave;y b&#7893; sung v&agrave;o b&#7857;ng ch&#7913;ng ng&agrave;y c&agrave;ng t&#259;ng r&#7857;ng l&atilde;o h&oacute;a c&oacute; th&#7875; t&#259;ng t&#7889;c t&#7841;i c&aacute;c &#273;i&#7875;m nh&#7845;t &#273;&#7883;nh. Tuy nhi&ecirc;n, c&aacute;c nghi&ecirc;n c&#7913;u l&#7899;n h&#417;n v&#7851;n c&#7847;n &#273;&#432;&#7907;c th&#7921;c hi&#7879;n tr&#432;&#7899;c khi c&aacute;c nh&agrave; khoa h&#7885;c c&oacute; th&#7875; g&#7855;n nh&atilde;n tu&#7893;i 50 l&agrave; m&#7897;t &#273;i&#7875;m kh&#7911;ng ho&#7843;ng. Maja Olecka, m&#7897;t nh&agrave; nghi&ecirc;n c&#7913;u l&atilde;o h&oacute;a t&#7841;i Vi&#7879;n Leibniz v&#7873; l&atilde;o h&oacute;a &#8211; Fritz Lipmann &#7903; Jena, &#272;&#7913;c, cho bi&#7871;t: &#8216;C&oacute; nh&#7919;ng &#273;&#7907;t thay &#273;&#7893;i li&ecirc;n quan &#273;&#7871;n tu&#7893;i t&aacute;c, nh&#432;ng v&#7851;n kh&oacute; &#273;&#432;a ra k&#7871;t lu&#7853;n chung v&#7873; th&#7901;i &#273;i&#7875;m c&#7911;a c&aacute;c &#273;i&#7875;m u&#7889;n.&#8217; &#272;i&#7873;u n&agrave;y cho th&#7845;y r&#7857;ng v&#7851;n c&ograve;n nhi&#7873;u c&acirc;u h&#7887;i c&#7847;n &#273;&#432;&#7907;c tr&#7843; l&#7901;i tr&#432;&#7899;c khi ch&uacute;ng ta c&oacute; th&#7875; hi&#7875;u r&otilde; h&#417;n v&#7873; qu&aacute; tr&igrave;nh l&atilde;o h&oacute;a v&agrave; c&aacute;ch th&#7913;c can thi&#7879;p v&agrave;o n&oacute;.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ph\u00e2n t\u00edch s\u1ef1 thay \u0111\u1ed5i c\u1ee7a protein theo th\u1eddi gian \u1edf c\u00e1c c\u01a1 quan kh\u00e1c nhau cho th\u1ea5y l\u00e3o h\u00f3a t\u0103ng t\u1ed1c kho\u1ea3ng tu\u1ed5i 50. M\u1ed9t s\u1ed1 m\u00f4 l\u00e3o h\u00f3a nhanh h\u01a1n nh\u1eefng m\u00f4 kh\u00e1c, \u0111\u1eb7c bi\u1ec7t l\u00e0 m\u1ea1ch m\u00e1u. Nghi\u00ean c\u1ee9u c\u0169ng x\u00e1c \u0111\u1ecbnh c\u00e1c ph\u00e2n t\u1eed c\u00f3 th\u1ec3 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a.<\/p>\n","protected":false},"author":1,"featured_media":1994,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3],"tags":[2419,2225,2420,2418,2421,1984],"class_list":["post-1993","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thoi-su","tag-co-quan","tag-lao-hoa","tag-mach-mau","tag-protein","tag-sinh-hoc","tag-tuoi-tho"],"_links":{"self":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/1993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/comments?post=1993"}],"version-history":[{"count":0,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/1993\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media\/1994"}],"wp:attachment":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media?parent=1993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/categories?post=1993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/tags?post=1993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}