{"id":1537,"date":"2025-08-08T23:40:36","date_gmt":"2025-08-08T16:40:36","guid":{"rendered":"https:\/\/nopphatnguoi.vn\/blog\/kham-pha-moi-lien-he-giua-vi-khuan-duong-ruot-va-suc-khoe-con-nguoi-bang-mang-than-kinh\/"},"modified":"2025-08-08T23:40:39","modified_gmt":"2025-08-08T16:40:39","slug":"kham-pha-moi-lien-he-giua-vi-khuan-duong-ruot-va-suc-khoe-con-nguoi-bang-mang-than-kinh","status":"publish","type":"post","link":"https:\/\/nopphatnguoi.vn\/blog\/kham-pha-moi-lien-he-giua-vi-khuan-duong-ruot-va-suc-khoe-con-nguoi-bang-mang-than-kinh\/","title":{"rendered":"Kh\u00e1m ph\u00e1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi b\u1eb1ng m\u1ea1ng th\u1ea7n kinh"},"content":{"rendered":"<div>\n<p>M&#7897;t nh&oacute;m c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u t&#7841;i &#272;&#7841;i h&#7885;c Tokyo &#273;&atilde; &#273;&#7841;t &#273;&#432;&#7907;c m&#7897;t b&#432;&#7899;c ti&#7871;n quan tr&#7885;ng trong vi&#7879;c hi&#7875;u r&otilde; m&#7889;i quan h&#7879; gi&#7919;a vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t v&agrave; s&#7913;c kh&#7887;e con ng&#432;&#7901;i. H&#7885; &#273;&atilde; &aacute;p d&#7909;ng m&#7897;t h&igrave;nh th&#7913;c tr&iacute; tu&#7879; nh&acirc;n t&#7841;o chuy&ecirc;n bi&#7879;t g&#7885;i l&agrave; m&#7841;ng l&#432;&#7899;i th&#7847;n kinh Bayes &#273;&#7875; ph&acirc;n t&iacute;ch d&#7919; li&#7879;u v&#7873; c&aacute;c vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t v&agrave; kh&aacute;m ph&aacute; nh&#7919;ng hi&#7875;u bi&#7871;t s&acirc;u s&#7855;c v&#7873; s&#7913;c kh&#7887;e con ng&#432;&#7901;i.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/media.tripmap.vn\/blog-npn\/2025\/08\/kham-pha-moi-lien-he-giua-vi-khuan-duong-ruot-va-suc-khoe-con-nguoi-bang-mang-than-kinh.webp\" alt=\"A simplified breakdown of the inputs, process, and outputs that make up the system. Credit: 2025 Tsunoda et al. CC-BY-ND\" width=\"100%\"><figcaption>A simplified breakdown of the inputs, process, and outputs that make up the system. Credit: 2025 Tsunoda et al. CC-BY-ND<\/figcaption><\/figure>\n<p>Vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t &#273;&oacute;ng vai tr&ograve; quan tr&#7885;ng trong m&#7897;t lo&#7841;t c&aacute;c t&igrave;nh tr&#7841;ng s&#7913;c kh&#7887;e, v&agrave; s&#7921; &#273;a d&#7841;ng c&#7911;a ch&uacute;ng c&#361;ng nh&#432; s&#7921; ph&#7913;c t&#7841;p c&#7911;a c&aacute;c t&#432;&#417;ng t&aacute;c v&#7899;i c&#7843; h&oacute;a h&#7885;c c&#7911;a c&#417; th&#7875; v&agrave; v&#7899;i nhau l&agrave;m cho ch&uacute;ng r&#7845;t kh&oacute; nghi&ecirc;n c&#7913;u. M&#7863;c d&ugrave; vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t th&#432;&#7901;ng &#273;&#432;&#7907;c li&ecirc;n k&#7871;t v&#7899;i ti&ecirc;u h&oacute;a, ch&uacute;ng c&#361;ng &#7843;nh h&#432;&#7903;ng &#273;&#7871;n m&#7897;t lo&#7841;t c&aacute;c ch&#7913;c n&#259;ng c&#417; th&#7875;, bao g&#7891;m c&#7843; h&#7879; mi&#7877;n d&#7883;ch, trao &#273;&#7893;i ch&#7845;t, ho&#7841;t &#273;&#7897;ng n&atilde;o v&agrave; t&acirc;m tr&#7841;ng.<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/media.tripmap.vn\/blog-npn\/2025\/08\/kham-pha-moi-lien-he-giua-vi-khuan-duong-ruot-va-suc-khoe-con-nguoi-bang-mang-than-kinh-2.webp\" alt=\"VBayesMM uses paired microbiome-metabolite data, with microbial species as input variables and metabolite abundances as target variables. Credit: 2025 Tsunoda et al. CC-BY-ND\" width=\"100%\"><figcaption>VBayesMM uses paired microbiome-metabolite data, with microbial species as input variables and metabolite abundances as target variables. Credit: 2025 Tsunoda et al. CC-BY-ND<\/figcaption><\/figure>\n<p>C&#417; th&#7875; con ng&#432;&#7901;i ch&#7913;a kho&#7843;ng 30 &#273;&#7871;n 40 ngh&igrave;n t&#7927; t&#7871; b&agrave;o, nh&#432;ng &#273;&#432;&#7901;ng ru&#7897;t ch&#7913;a kho&#7843;ng 100 ngh&igrave;n t&#7927; vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t. &#272;i&#7873;u n&agrave;y c&oacute; ngh&#297;a l&agrave; c&aacute;c t&#7871; b&agrave;o vi khu&#7849;n trong c&#417; th&#7875; ch&uacute;ng ta nhi&#7873;u h&#417;n s&#7889; l&#432;&#7907;ng t&#7871; b&agrave;o c&#7911;a ch&iacute;nh ch&uacute;ng ta. &#272;&#7875; hi&#7875;u r&otilde; m&#7889;i quan h&#7879; gi&#7919;a vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t v&agrave; s&#7913;c kh&#7887;e con ng&#432;&#7901;i, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;ang ch&#7881; b&#7855;t &#273;&#7847;u hi&#7875;u &#273;&#432;&#7907;c lo&#7841;i vi khu&#7849;n n&agrave;o t&#7841;o ra ch&#7845;t chuy&#7875;n h&oacute;a c&#7911;a con ng&#432;&#7901;i v&agrave; l&agrave;m th&#7871; n&agrave;o c&aacute;c m&#7889;i quan h&#7879; n&agrave;y thay &#273;&#7893;i trong c&aacute;c b&#7879;nh kh&aacute;c nhau.<\/p>\n<p>&#272;&#7875; gi&#7843;i quy&#7871;t th&aacute;ch th&#7913;c n&agrave;y, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u &#273;&atilde; &aacute;p d&#7909;ng c&ocirc;ng c&#7909; tr&iacute; tu&#7879; nh&acirc;n t&#7841;o ti&ecirc;n ti&#7871;n g&#7885;i l&agrave; VBayesMM &#273;&#7875; ph&acirc;n t&iacute;ch d&#7919; li&#7879;u. H&#7879; th&#7889;ng n&agrave;y t&#7921; &#273;&#7897;ng ph&acirc;n bi&#7879;t c&aacute;c y&#7871;u t&#7889; quan tr&#7885;ng &#7843;nh h&#432;&#7903;ng &#273;&#7871;n ch&#7845;t chuy&#7875;n h&oacute;a t&#7915; s&#7889; l&#432;&#7907;ng l&#7899;n c&aacute;c vi khu&#7849;n &iacute;t li&ecirc;n quan, &#273;&#7891;ng th&#7901;i th&#7915;a nh&#7853;n s&#7921; kh&ocirc;ng ch&#7855;c ch&#7855;n v&#7873; c&aacute;c m&#7889;i quan h&#7879; d&#7921; &#273;o&aacute;n.<\/p>\n<p>Khi &#273;&#432;&#7907;c th&#7917; nghi&#7879;m tr&ecirc;n d&#7919; li&#7879;u th&#7921;c t&#7915; c&aacute;c nghi&ecirc;n c&#7913;u v&#7873; r&#7889;i lo&#7841;n gi&#7845;c ng&#7911;, b&eacute;o ph&igrave; v&agrave; ung th&#432;, ph&#432;&#417;ng ph&aacute;p n&agrave;y &#273;&atilde; li&ecirc;n t&#7909;c v&#432;&#7907;t tr&#7897;i so v&#7899;i c&aacute;c ph&#432;&#417;ng ph&aacute;p hi&#7879;n c&oacute; v&agrave; x&aacute;c &#273;&#7883;nh c&aacute;c gia &#273;&igrave;nh vi khu&#7849;n c&#7909; th&#7875; ph&ugrave; h&#7907;p v&#7899;i c&aacute;c qu&aacute; tr&igrave;nh sinh h&#7885;c &#273;&atilde; bi&#7871;t. &#272;i&#7873;u n&agrave;y mang l&#7841;i s&#7921; t&#7921; tin r&#7857;ng h&#7879; th&#7889;ng n&agrave;y ph&aacute;t hi&#7879;n ra c&aacute;c m&#7889;i quan h&#7879; sinh h&#7885;c th&#7921;c s&#7921; ch&#7913; kh&ocirc;ng ph&#7843;i l&agrave; c&aacute;c m&#7851;u th&#7889;ng k&ecirc; kh&ocirc;ng c&oacute; &yacute; ngh&#297;a.<\/p>\n<p>M&#7863;c d&ugrave; h&#7879; th&#7889;ng &#273;&#432;&#7907;c t&#7889;i &#432;u h&oacute;a &#273;&#7875; &#273;&#7889;i ph&oacute; v&#7899;i kh&#7889;i l&#432;&#7907;ng ph&acirc;n t&iacute;ch n&#7863;ng, vi&#7879;c khai th&aacute;c c&aacute;c t&#7853;p d&#7919; li&#7879;u l&#7899;n v&#7851;n &#273;i k&egrave;m v&#7899;i chi ph&iacute; t&iacute;nh to&aacute;n cao. Tuy nhi&ecirc;n, khi th&#7901;i gian tr&ocirc;i qua, r&agrave;o c&#7843;n n&agrave;y s&#7869; tr&#7903; n&ecirc;n &iacute;t quan tr&#7885;ng h&#417;n.<\/p>\n<p>C&aacute;c h&#7841;n ch&#7871; hi&#7879;n t&#7841;i bao g&#7891;m vi&#7879;c h&#7879; th&#7889;ng c&oacute; l&#7907;i khi c&oacute; nhi&#7873;u d&#7919; li&#7879;u v&#7873; vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t h&#417;n l&agrave; v&#7873; c&aacute;c ch&#7845;t chuy&#7875;n h&oacute;a m&agrave; ch&uacute;ng t&#7841;o ra. Khi d&#7919; li&#7879;u v&#7873; vi khu&#7849;n kh&ocirc;ng &#273;&#7911;, &#273;&#7897; ch&iacute;nh x&aacute;c gi&#7843;m. Ngo&agrave;i ra, VBayesMM gi&#7843; &#273;&#7883;nh r&#7857;ng c&aacute;c vi khu&#7849;n ho&#7841;t &#273;&#7897;ng &#273;&#7897;c l&#7853;p, nh&#432;ng tr&ecirc;n th&#7921;c t&#7871;, ch&uacute;ng t&#432;&#417;ng t&aacute;c theo nhi&#7873;u c&aacute;ch ph&#7913;c t&#7841;p.<\/p>\n<p>Trong t&#432;&#417;ng lai, c&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u c&oacute; k&#7871; ho&#7841;ch l&agrave;m vi&#7879;c v&#7899;i c&aacute;c t&#7853;p d&#7919; li&#7879;u h&oacute;a h&#7885;c to&agrave;n di&#7879;n h&#417;n &#273;&#7875; b&#7855;t to&agrave;n b&#7897; ph&#7841;m vi s&#7843;n ph&#7849;m c&#7911;a vi khu&#7849;n, m&#7863;c d&ugrave; &#273;i&#7873;u n&agrave;y t&#7841;o ra th&aacute;ch th&#7913;c m&#7899;i trong vi&#7879;c x&aacute;c &#273;&#7883;nh h&oacute;a ch&#7845;t &#273;&#7871;n t&#7915; &#273;&acirc;u. H&#7885; c&#361;ng nh&#7857;m m&#7909;c &#273;&iacute;ch l&agrave;m cho VBayesMM m&#7841;nh m&#7869; h&#417;n khi ph&acirc;n t&iacute;ch d&acirc;n s&#7889; b&#7879;nh nh&acirc;n &#273;a d&#7841;ng, k&#7871;t h&#7907;p m&#7889;i quan h&#7879; &#8216;c&acirc;y gia &#273;&igrave;nh&#8217; c&#7911;a vi khu&#7849;n &#273;&#7875; &#273;&#432;a ra d&#7921; &#273;o&aacute;n t&#7889;t h&#417;n v&agrave; gi&#7843;m th&#7901;i gian t&iacute;nh to&aacute;n c&#7847;n thi&#7871;t cho ph&acirc;n t&iacute;ch.<\/p>\n<p>&#272;&#7841;i h&#7885;c Tokyo &#273;&atilde; v&agrave; &#273;ang th&#7921;c hi&#7879;n nhi&#7873;u nghi&ecirc;n c&#7913;u v&#7873; vi khu&#7849;n &#273;&#432;&#7901;ng ru&#7897;t v&agrave; s&#7913;c kh&#7887;e con ng&#432;&#7901;i. C&aacute;c nh&agrave; nghi&ecirc;n c&#7913;u hy v&#7885;ng r&#7857;ng nh&#7919;ng ph&aacute;t hi&#7879;n n&agrave;y s&#7869; gi&uacute;p ph&aacute;t tri&#7875;n c&aacute;c ph&#432;&#417;ng ph&aacute;p &#273;i&#7873;u tr&#7883; c&aacute; nh&acirc;n h&oacute;a v&agrave; c&#7843;i thi&#7879;n s&#7913;c kh&#7887;e con ng&#432;&#7901;i.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Tokyo \u0111\u00e3 s\u1eed d\u1ee5ng m\u1ea1ng n\u01a1-ron Bayes \u0111\u1ec3 ph\u00e2n t\u00edch m\u1ed9t t\u1eadp d\u1eef li\u1ec7u l\u1edbn v\u1ec1 h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t, nh\u1eb1m kh\u00e1m ph\u00e1 nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u s\u1eafc v\u1ec1 s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi. Vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong nhi\u1ec1u t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe v\u00e0 s\u1ef1 t\u01b0\u01a1ng t\u00e1c c\u1ee7a ch\u00fang v\u1edbi sinh h\u00f3a c\u01a1 th\u1ec3 v\u00e0 v\u1edbi nhau khi\u1ebfn ch\u00fang kh\u00f3 nghi\u00ean c\u1ee9u. B\u1eb1ng c\u00e1ch l\u1eadp b\u1ea3n \u0111\u1ed3 ch\u00ednh x\u00e1c c\u00e1c m\u1ed1i quan h\u1ec7 gi\u1eefa vi khu\u1ea9n v\u00e0 h\u00f3a ch\u1ea5t, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00e1 nh\u00e2n h\u00f3a cho nhi\u1ec1u lo\u1ea1i b\u1ec7nh b\u1eb1ng c\u00e1ch nh\u1eafm v\u00e0o c\u00e1c nh\u00f3m vi khu\u1ea9n c\u1ee5 th\u1ec3 ho\u1eb7c thi\u1ebft k\u1ebf c\u00e1c li\u1ec7u ph\u00e1p nh\u1eafm v\u00e0o c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a.<\/p>\n","protected":false},"author":1,"featured_media":1540,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3],"tags":[1939,1940,1938,1941,1936,1937],"class_list":["post-1537","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thoi-su","tag-dai-hoc-tokyo","tag-mang-no-ron-bayes","tag-nghien-cuu-khoa-hoc","tag-phan-tich-du-lieu","tag-suc-khoe-con-nguoi","tag-vi-khuan-duong-ruot"],"_links":{"self":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/1537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/comments?post=1537"}],"version-history":[{"count":0,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/posts\/1537\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media\/1540"}],"wp:attachment":[{"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/media?parent=1537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/categories?post=1537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nopphatnguoi.vn\/blog\/wp-json\/wp\/v2\/tags?post=1537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}